Chapter 3: Fact vs. Fiction

68 Negative impact of Women’s Health Initiative: Ob Gyn News October 1, 2006. Dixon BK.
70 Premarin increases inflammation: Maturitas. 2003 Dec 10;46(4):245-53. Yilmazer M et al.; Atherosclerosis. 2006 Dec;189(2):436-42. Sumino H et al.; Menopause. 2005 Sep-Oct;12(5):552-8. Vitale C et al.; Atherosclerosis. 2006 Apr;185(2):347-52. Hu P et al.
70 Bioidentical estradiol in cream form decreases inflammation:Gynecol Obstet Mex. 2006 Mar;74(3):133-8. Saucedo Garcia R et al.; Cytokine. 2005 Aug;31(4):251-7 Liu H et al.; J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):53-8. WangY et al.; Rheumatol Int. 2003 Nov;23(6):282-8. Lee YJ et al.
70 Bioidentical estradiol does not increase CRP: Maturitas. 2005 Oct 16;52(2):111-8. Eilertsen AL et al.; Menopause. 2006 Sep-Oct;13(5):840-5. Rachon D et al.; Maturitas. 2003 Dec 10;46(4):245-53. Yilmazer M et al.
70 Premarin and bioidential estradio in capsule/pill form increase CRP: Maturitas. 2005 Oct 16;52(2):111-8. Eilertsen AL et al.
71 Premarin increases body fat and decreases lean body mass:Adv Ther. 2006 Mar-Apr;23(2):263-73. Delibasi T et al.
71 Bioidentical estradiol decreases body fat: Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1251-63. Asarian L et al.; Psychol Med. 2006 Oct 12;:1-11. Edler C et al.; Fertil Steril. 2006 Dec;86(6)1669. Micheline CC et al
71 Bioidentical estradiol promotes muscle growth and regeneration: J Appl Physiol. 2006 Jun;100(6):2012-23. McClung JM et al.
71 Premarin increases cardiovascular events: Arch Intern Med. 2006 Feb 27;166(4):399-404. Lemaitre RN et al.; Atherosclerosis. 2006 Apr;185(2):347-52. Hu P et al.
71 Premarin increases atherosclerotic vascular disease: Hum Reprod. 2006 Oct;21(10):2715-20. Ho JY et al.
71 Premarin increases venous thrombosis: Arch Intern Med. 2006 Apr;166((7):772-80 Curb JD et al.
71 Bioidentical estradiol cream does not increase blood clots or venous thrombosis: Circulation. 2007 Feb 20;115(7):840-5. Canonico M et al.
71 Bioidentical estradiol protects the heart: Menopause. 2006 Jul-Aug;13(4):643-50. Zegura B et al.; Basic Res Cardiol. 2006 Jul 4; Beer S et al.; Menopause. 2001 Jul-Aug:8(4):252-8. Ventura P et al.; Ob Gyn News April 15 2005. Wildman RP. Page 28.; Fertil Steril. 2004:82:391-7. Mack WJ et al.; Ann NY Acad Sci. 1990;592:193-203. Stampfer M et al.; Hypertens Res. 2005 Jul;28(7):579-84. Sumino H et al.
71 Premarin Increases systemic lupus erythematosus flares: Ann Intern Med.
2005 Jun 21;142(12 Pt 1):953-62. Buyon JP et al
71 Premarin increases migraines: Maturitas. 2001 Apr 20;38(2):157-63. Nappi RE et al.
71 Bioidentical estradiol is effective treatment for migraine: New Advance In Headache Research 4th add London-Smith Gordon 1999:129. Predalier A et al.; Neurology. 1972 Apr;22(4):355-65. Somerville BW.; Neurology. 2006 Sep 13: Macgregor EA et al.; Headache 2006 Oct;46 Suppl 2:S49-54. Zacur HA.
71 Premarin decreases co-enzyme Q10 and vitamin gamma-E:Biofactors. 2005;25(1-4):61-6. Palan PR et al.
72 Premarin increases stress incontinence: JAMA. 2005 Feb 23;293(8):935-48. Hendrix SL et al.; Menopause. 2005 Mar;12(2):160-4. Goldstein SR et al.
72 Premarin increases Dry Eye Syndrome: 
Gynecol Endocrinol. 2006 Sep;22(9):501-5. Uncu G et al
72 Bioidentical estrogen decreases Dry Eye Syndrome:
Gynecol Endocrinol. 2005 May;20(5):289-98. Versura P et al
73 Bioidentical progesterone protects from breast cancer: Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10506-11. Nilsen J.; J Steroid Biochem Mol Biol. 2001 Aug;78(2):185-91. McDonnel AC et al.; Clin Cancer Res. 2001 Sep;7(9):2880-6. Lin VC et al.; Am J Epidemiol. 1981;114(2):209-17 Cowan LD.; Int J Cancer. 2005 Apr10;114(3):448-54. Fournier A.; Pathol Biol. 1987;35:1081-86. Mauvais-Jarvis P.; Ann NY Acad Sci. 1986;464:152-67. Mauvais-Jarvis P.; Cancer Detect Prev. 1999;23:290-298. Plu-Bureau G.; Climacteric.2002;5:332-40. Lignieres B.; Breast Cancer Res Treat. 2006 Jul 14; Wood CE.; J Steroid Biochem Mol Biol. 2006 Oct 16; Mendelson CR.; Breast J. 2006 Nov;12(6):518-525. Kontos M.; J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):241-9. Mendelson CR et al.
73 Provera and other chemicalize progestin promotes breast cancer: Cancer. 2003;97(6):1387. Olsson el al.; Oncogene. 2006 Dec 14;25(59):7723-39. Salatino M et al.; Breast Cancer Res Treat. 2006 Jul 14; Wood CE et al; Horm Metab Res. 2005 Aug;37(8):468-73. Seeger H et al.; BMC Cancer. 2006 Oct 18;6:246. Eigeliene N et al.; Endocrinology. 2005 Nov;146(11):4917-25. Saitoh M et al.; J National Cancer Institute. 2000;92(4):328-32. Ross RK et al; Int J Cancer. 1999;81(3):339. Magnusson C et al.; FASEB. 2007 Aug;21(10):2285-93. Birrell SN et al
73 Bioidentical progesterone does not promote diabetes: Euro J Endo.1999;140(3):215-223. Cucinelli F et al.; Exp Physiol. 2007 Jan;92(1):241-9. Ordonez et al.
73 Provera increases diabetes: Diabetes Care. 2006 Mar;29(3):613-7. Xiang AH et al.; Am J Obstet Gynecol. 2006 Feb;194(2):355-61. Goodrow GJ et al.; Arch Intern Med. 2001;161:1766-1771. Kim C. et al
73 Bioidentical progesterone builds bone: Endocr Res. 2003 Nov;29(4):483-501. Liang M et al.; Di Yi Jun Yi Da Xue Xue Bao. 2001;21(12):929-931. Zhang P et al.; Calcif Tissue Int. 2002 Oct;71(4):329-34. Luo XH et al.; J Tongji Med Univ. 2000;20(1):59-62. Chen L. et al.; Zhonghua Fu chan Ke Za Zhi. 1997 Sep;32(9):538-40. Chen L et al.; Zhonghua Fu chan Ke Za Zhi. 2004 Apr;39(4):250-3. Liang M et al.; Fertil Steril. 2006 Nov;86(5):1466-74. Clark MK et al.; Arch Pediatir Adolesc Med. 2005 feb;159(2):139-44. Scholes D et al.
73 Provera cause bone loss: Menopause 2001;8(1):10-16. Montplaisir J et al.; Fertil Steril. 2004 Dec;82(6):1580-6 Clark MK et al.
73 Bioidentical progesterone protects the heart: Arterio Thromb Vas Biol. 2001;21:243-8. Otsuki M et al.; Arterio Thromb Vas boil. 2004;24:955-961. Hermsmeyer RK et al.; J A Coll Cardiol. 2000 Dec;36(7):2154-9. Rosano GM et al.
73 Provera destrucitive to the cardio vascular system and the heart: Circulation. 2002 Sep 24;106(13):1646-51. Sorensen MB et al.; J Am Coll Cardiol. 2000 Dec;36(7):2154-9. Rosano GM et al.; Menopause. 2006 Jan-Feb;13(1):80-6. Jeanes HL et al.; Hypertension. 2006 Nov;48(5):994-1001. Arias-Loza PA et al.; J Am Coll Cardiol. 1994 Dec;24(7):1757-61. Williams JK et al.; Steroids. 2006 Sep;71(9):834-42. Pederses DH et al.; Menopause. 2006 Jan-Feb;13(1):80-6. Jeanes HL et al.; Aterioscler Thromb Vasc. Biol. 1998 Jul;18(7):1164-71. Register TC et al.; Circulation. 2001 Oct 9;104(15)):1773-8. Wakatsuki A et al.
73 Bioidentical progesterone promotes better sleep: Poster Endocrinology Conference. 2004 New Orlearns Callfries A.; Menopause. 2001;8(1):10-16. Montplaisir J et al.; Curr Med Chem. 2006;13(29):3575-82. Andersen ML et al.
73 Provera decrease sleep quality: Jpn J Psychiatry Neurol. 1987 Jun;41(2):261-7. Kotorii T et al.
73 Provera negative affects on the immune system: Virology. 2006 Aug 15;352(1):169-77. Trunova N et al.
73 Provera is destructive to the brain: Poster Endocrinology Conference. 2004 New Orlearns Callfries A.; Endocrine. 2006 Apr;29(2):271-4. Singh M.; Gynecol Endocrinol. 2006 Jul;22(7):355-61. Nilsen J et al.
73 Provera is known to induce neuron-degenerative diseases:Gynecol Endocrinol. 2006 Jul;22(7):355-61. Nilsen J.; J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):205-13. Pluchino N et al.; Proc Natl Acad Sci USA. 2003 Sep 2;100(18):10506-11. Nilsen J et al.; J Neurobiol. 2006 Aug;66(9):916-28. Ciriza I et al.
73 Bioidentical progesterone protects neurological system: J Neurobiol. 2006 Aug;66(9):916-28. Ciriza I et al.; Endocrine. 2006 Apr;29(2):271-4. Singh M.; J Neurotrauma. 2006 Feb;23(2):181-92. Labombarda F et al.; J Neuroendocrinol. 2004 Jan;161(1):58-63. Ciriza I et al.; Neuro Endocrinol Lett. 2006 Oct;27(5):675-8. Muller E et al.; Pharmacol Biochem Behav. 2006 Jul;84(3):420-8. Cutler SM et al.; J Mol Neurosci. 2006;28(1):3-15. De Nicola AF et al.; J Neurosci Res. 2007 Aug 15;85(11):2441-9. Kaur P et al.; Exp Neurol. 2007 Feb;203(2):406-14. Gonzalez Deniselle MC et al.
73 Provera promotes aggressive feelings: Pharmacol Biochem Behav. 2006 Jul;84(3):420-8. Cutler SM et al.
73 Provera promotes anxiety and depression: J Women’s Health Gend Base Med.
2000 May;9(4):381-387. Fitzpatrick LA et al.
74 Provera increases seizures: Epilepsia. 2006 Sep;47(9):1447-51. Harden CL et al.
74 Bioidentical progesterone increases GABA and allopregnenolone and is a brain calmer: J Neuro Endocrinol. 1995 Mar;7(3):171-7. Bitrn D.; Brain Res. 1995 May 22;680(1-2):135-41. Picazo O et al.; J Women’s Health Gend Base Med. 2000 May;9(4):381-7. Fitzpatrick LA et al.; J Neuroendocrinol. 2004 Jan;161(1):58-63. Ciriza I et al.
74 Provera negatively affects hearing: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14246-9. Guimaraes P et al.
73 Bioidentical progesterone has a positive affect on hearing:Neuropsychologia. 2002;40(8):1293-9. Alexander GM et al.
74 Provera may promote allergy, IBS and IC by increasing mast cells: Hum Reprod. 2000 Jan;15(1):123-30. Vincent AJ et al.
74 Bioidentical progesterone decreases mast cells: Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):787-94. Vasiadi M et al.
74 Bioidentical progesterone decreases water retention: Horm Metab Res. 2004 Jun;36(6):381-6. Quinkler M et al.
74 The scientific community is aware of the significant dangers associated with provera use: Menopause. 2001;8(1):10-16. Montplaisir J et al.; Cancer. 2003;97(6):1387-92. Olsson HL et al.; J A Coll Cardiol. 2000 Dec;36(7):2154-9. Rosano GM et al.; Epilepsia. 2006 Sep;47(9):1447-51. Harden CL et al.; Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14246-9. Guimaraes P et al.; Endocrine. 2006 Apr;29(2):271-4. Singh M.; Menopause. 2006 Jan-Feb;13(1):80-6. Jeanes HL et al.; Oncogene. 2006 Dec 14;25(59):7723-39. Salatino M et al.; Gynecol Endocrinol. 2006 Jul;22(7):355-61. Nilsen J et al.; J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):205-13. Pluchino N et al.; Hypertension. 2006 Nov;48(5):994-1001. Arias-Loza PA et al.; Fertil Steril. 2004 Dec;82(6):1580-6. Clark MK et al.; Fertil Steril. 2006 Nov;86(5):1466-74. Clark MK et al.; Horm Metab Res. 2005 Aug;37(8):468-73. Seeger H et al.; BMC Cancer. 2006 Oct 18;6:246. Eigeliene N et al.; Endocrinology. 2005 Nov;146(11):4917-25. Saitoh M et al.; Hum Reprod. 2000 Jan;15(1):123-30. Vincent AJ et al.; J National Cancer Institute. 2000 Feb 16;92(4):328-32. Ross RK et al.; Int J Cancer. 1999;81(3):339. Magnusson C.; Diabetes Care. 2006 Mar;29(3):613-7. Xiang AH.; Ann Clinic Biochem. 1996 May;33(Pt 3):187-9. Malik KJ et al.; Sex Transm Dis. 2004 Sep;31(9):561-7. Morrison CS et at.; Arch Pediatr Adolesc Med. 2005 Feb;159(2):139-44. Scholes D et al.; Acta Obstet Gynecol Scand. 2004 Oct;83(10):909-11. Ziaei S et al.; Virology. 2006 Aug 15;352(1):169-77. Trunova N et al.; AIDS. 2004 Jan 23;18(2):205-9. Wang CC et al.; J Infect Dis. 1998 Oct;178(4):1053-9. Martin HL Jr et al.

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