Chapter 14: Sleep and Insomnia

273 Definition of insomnia: Am J Med. 2006 Jun;119(6):463-9. Kamel NS et al.
273 10% of Americans suffer from insomnia; 25-35% suffer occasionally: Am J Manag Care. 2006 May;12(8 Suppl):S214-20. Doghramji K.
274 Insomnia afflicts more women; more so as they age: Am J Med. 2006 Jun;119(6):463-9. Kamel NS et al.
275 Body does not allow sleep when under stress: Psychosom Med. 2003 Mar-Apr;65(2):259-67. Morin CM et al.
276 Abnormal sleep patterns correlate to lower life expectancy:Am J Manag Care. 2006 May;12(8 Suppl):S214-20. Doghramji K.
276 One third to half of insomniacs suffer from mood disorders and substance abuse: Sleep Med rev. 2000 Jun;4(3):253-262. Lustberg L et al.; Sleep Med Rev. 1997 Nov;1(1):45-56. Benca RM et al.
276 Sleep disorders increase incidents of cardiovascular disease and related death: J Psychosom Res. 1999 Oct;47(4):313-33. Schwartz S et al.; Ann Epidemiol. 1998 Aug;8(6):384-92. Schwartz SW et al.
276 Sleep deficiency may bring on/enhance depression: Sleep Med Rev. 2000 Jun;4(3):253-262. Lustberg L et al.
277 Stress and anxiety can enhance insomnia: Psychosom Med. 2003 Mar-Apr;65(2):259-67. Morin CM et al.
277 Insomnia enhance headaches: Sleep Med Rev. 2002 Dec;6(6):471-9. Jennum P.
281 Estrogen and progesterone should be first line of defense against insomnia: J Br Menopause Soc. 2004 Dec;10(4):145-50. Polo-Kantola P et al.
282 Melatonin found throughout the natural world: FEBS J. 2006 Jul;273(13):2813-38. Pandi-Perumal SR et al.
282 Melatonin hormone produced in retina, gastrointestinal tract, skin, bone marrow and lymphocytes: FEBS J. 2006 Jul;273(13):2813-38. Pandi-Perumal SR et al.
282 Melatonin is free-radical scavenger: Comb Chem High Throughput Screen. 2006 Jul;9(6):409-19. Suzen S.; FEBS J. 2006 Jul;273(13):2813-38. Pandi-Perumal SR et al.; J Endocrinol Invest. 2006 Mar;29(3):281-7. Aydogan S et al.; Behav Brain Funct. 2006 May 4;2(1):15. Srinivasan V et al.; Biosci Rep. 2007 Sep 7 7; Maharaj DS et al.; J endocrinol. 2007 Sep;194(3):637-43. Rodriguez MI et al.
282 Melatonin deficiency increase weight gain and depression: J Soc Biol. 2007;
201(1):105-13. Guardiola-Lemaitre PB.
282 Melatonin alleviates depression improving thyroid function:Ann N Y Acad Sci. 2005 Dec;1057:393-402. Bellipanni G et al.; J Psychiatry Neurosci. 2000 
283 Melatonin decreases anxiety: Prog Neuropsychopharmacol Biol Psychiatry.
2000 Jan;24(1):117-29. Naranjo-Rodriguez EB et al.
283 Melatonin promotes blood platelets health: Neuro Endocrinol Lett. 2006 Aug 5;27(4). Bella LD.
283 Melatonin prevent post surgical adhesions: Yonsei Med J. 2007 Aug 31;48(4):659-64. Hatipoglu A et al.
283 In ulcerative colitis, melatonin repairs damage to the mucosal of the GI system: Dig Dis Sci. 2006 Sep;51(9):1538-45. Necefli A et al.
283 Melatonin repair duodenal ulcer: Klin Med (Mosk). 2006;84(1):5-11. Malinovskaia N K et al.
283 Melatonin repair acute esophageal ulcer; J Physiol Pharmacol. 2007 Jun;58(2):361-77. Konturek SJ et al.
283 Melatonin maybe the future treatment for all acid reflux problems: Pol Merkur Lekarski. 2007 May;22(131):332-5. Walecka-Kapica E et al. 
283 Melatonin helps heal tinnitus: Otolaryngol Head Neck Surg. 2006 Feb;134(2):210-3. Megwalu UC et al.
283 Melatonin may protect from ALS: J Pineal Res. 2006 Nov;41(4):313-23. Weishaupt JH et al.
283 Melatonin may protect from Alzheimer’s; Behav Brain Funct. 2006 May4;291):15. Srinivasan V et al.
283 Melatonin helps alleviate hypertension: Am J Hypertens. 2005 Dec;18(12 Pt 1):1614-8. Cagnacci A et al.
283 Melatonin decrease endometriosis: Fertil Steril. 2007 Jun 18; Guney M et al.
283 Melatonin boosts and improves immune system: Med Sci Monit. 2006 Aug 25;12(9): BR307-312. Ergun Y et al.; Mol Cell Biochem. 2006 Aug 24. Cubero J et al.; Expert Opin Invest 16 Drugs. 2001 Mar;10(3):467-76. Maestroni GJ et al.
284 Melatonin reduces cholesterol levels: Nuero Endocrinol Lett. 2002 Apr;23(1):79-83. Sewerynek E.
284 Melatonin decreases brain vascular damage: Neurosci Lett. 2002 Feb 1;318(3):141-4.
284 Meltatonin is used for treating cluster headaches: Curr Pain Headache Rep. 2006 Apr:10(2):147-52. Sillman M.
284 Women with lower levels of melatonin are more likely to suffer migraines: CNS Drugs. 2006;20(5):343-50. Vogler B et al.
284 Melatonin treatmet for migraines: CNS Drugs. 2006;20(5):343-50. Vogler B et al.
284 Melatonin increases glutathione formation: Neuro Endocrinol Lett. 2006 Jun 2;27(3). Swiderska-Kolacz G et al.
284 Melatonin protects kidney from damage caused by kidney infection: Urology. 2006 Jun;67(6):1315-9. Imamoglu M et al.
284 Melatonin improves and resolves dry eye syndrome: Eur J Pharmacol. 2006 Dec 15;552(1-3):159-61. Hoyle CH et al.
284 Melatonin helps combat damaging effect of high blood sugar: Acta Histochem. 2006;108(2):85-93. Guven A et al.
284 Melatonin protects against osteoporosis: J Pineal Res. 2003 Mar;34(2)143-51. Ladizesky MG et al.
285 Melatonin inhibits proliferation and metastasis of cancerous tumors: Cancer Detect Prev. 2006;30(2):118-28. Cos S et al.
285 Melatonin may protect from pancreatic cancer: J Pineal Res. 2007 Oct;43(3):270-5. Ruiz –Rabelo JF et al.
285 Melatonin increases efficacy and decreases side effect of chemotherapy: Cancer Res. 2006 Oct 15;66(20):9789-93. Jung B et al.
285 Melatonin acts as a natural aromatase inhibitor: J Pineal Res. 2005 Mar;38(2):136-42. Cos et al.
285 Melatonin and Vitamin D-3 increases the realease of TGF Beta 1, reduce growth of breast cancer: J Surg Res. 2003 Apr;110(2):332-7. Bizzarri M et al.
285 Melatonin is able to reverse the decline and rise of hormonal function associated with aging: Ann N Y Acad Sci. 2005 Dec;1057:393-402. Bellipanni G et al.
286 In post-menopausal women, melatonin suppresses rise of LH: BMC Womens Health. 2006 May 16;6:8. Kripke DF et al.
286 Increase of FSH and LH is first sign of decreased ovarian function and an aging hormonal system: BMC Womens Health. 2006 May 16;6:8. Kripke DF et al.
286 Six-month treatment with melatonin changes gonadotropin:Ann N Y Acad Sci. 2005 Dec;1057:393-402. Bellipanni G et al.
286 Melatonin in high doses has contraceptive effects: Eur J Obstet Gynecol Reprod Biol. 1993 Apr;49(1-2):3-9. Silman RE et al.
286 Melatonin improves brain’s response to inflammation: J Neuroimmunol. 2006 Oct 27. Perreau VM et al.
286 Melatonin helps with jet-lag: Uqeskr Laeger. 2001 Jan 8;163(2):149-55. Christiansen AL et al.; Chochrane Database Syst Rev. 2002;(2):CD00152. Herxheimer A et al.; BMJ. 1989 Mar 18;298(6675):705-7. Petrie K et al.; J Mol Microbiol Biotechnol. 2002 Sep;495):463-6. Parry BL.
286 Melatonin significant sleep aid: FEBS J. 2006 Jul;273(13):2813-38. Pandi-Perumal SR et al.; J Am Acad Child Adolesc Psychiatry. 2007 Feb;46(2):233-41. Van der Heijden KB et al.; Z Gerontol Geriatr. 2001 Dec;34(6):491-7. Olde Rikkert MG et al.; Curr Med Res Opin. 2007 Sep 14; Wade AG et al.
287 Using Melatonin with Arginine to decrease oxidative damage of NO: J Endocrinol Invest. 2006 Mar;29(3):281-7. Aydogan S et al
287 Melatonin help fertility: J Pineal res. 2007 Oct;43(3):283-8. Rodriguez-Osorio N et al.

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