Chapter 1: Diet & Nutritional Pillar

21 Consistent proof that eating less is scientifically proven to increase lifespan extension: JAMA. 2004 Mar 10;291(10): 1226-30. Michels KB et al.
21 Medical studies consistently proving that eating less increases lifespan: Microsc Res Tech. 2002 Nov 15;59(4): 335-8. Lane MA et al.
21 Caloric reduction improves insulin sensitivity and decreases midsection fat: Toxicol Sci. 1999 Dec;52(2 Suppl): 49-55. Cefalu WT et al.; J Gerontol A Biol Sci Med Sci. 2004 Oct;59(10): 1007-14. Cefalu WT et al.
21 Caloric reduction reduces LDL cholesterol, triglycerides and weight: Free Radic Biol Med. 2007 Mar 1;42(5): 665-74. Johnson JB et al.
22 Calorie reduction lowers rate of mitochondrial free-radical cell formation:
Int J Biochem Cell Biol. 2002 Nov;34(11):1340-54. Merry BJ et al.
22 Calorie reduction lowers marker of oxidative stress: Proc Natl Acad Sci U S A. 2006 Dec 26;103(52): 19908-12. Hyun DH et al.
22 Calorie reduction decreases TNF alpha and increases natural antioxidants: Free Radic Biol Med. 2007 Mar 1;42(5): 665-74. Johnson JB et al.
22 Calorie reduction benefits breast cancer: JAMA. 2004 Mar 10;291(10): 1226-30. Michels KB.; Exp Biol Med (Maywood). 2007 Jan;232(1): 70-80. Cleary MP et al.; Interdiscip Top Gerontol. 2007;35: 176-92. Klebanov S.
22 Calorie reduction protects genome by increasing repair and decreasing mutation: J Nutr Health Aging. 1999;3(2): 102-10. Raffoul JJ et al.
22 Calorie reduction produces new neurons, increases apatosis and helps DNA repair itself: Ann N Y Acad Sci. 2004 Jun;1019: 96-105. Hiona A et al.
22 Calorie reduction decreases brain inflammation: Interdiscip Top Gerontol. 2007;35: 83-97. Morgan TE et al.
22 Calorie reduction decreases oxidative stress in brain: Proc Natll Acad Sci U S A. 2006 Dec 26;103(52): 19908-12. Hyun DH et al.
22 Calorie reduction decreases brain toxicity and increases memory consolidation: Brain Res Mol Brain Res. 2000 May 31;78(1-2): 154-62. Eckles-Smith K et al.; Neuroreport. 2005 Jul 13;16(10): 1129-33. Hashimoto T et al.
22 50% calorie reduction in obese women improves word recall:Int J Obes Relat Metab Disord. 1997 Jan;21(1): 14-21. Kretsch MJ et al.
23 Caloric reduction programs show promise in reducing incidence of Alzheimer's: Interdiscip Top Gerontol. 2007;35: 159-75. Pasinetti GM et al.
23 Bone loss with caloric reduction is mitigated if accompanied by physical activity: Arch Intern Med. 2006 Dec 11-25;166(22): 2502-10. Villareal DT et al.
23 Caloric reduction prevents muscle fiber loss: FASEB J. 2004 Mar;18(3): 580-1. McKiernan SH et al.
23 Caloric reduction preserves aerobic function in aging muscle:FASEB J. 2005 Aug;19(10): 1320-2. Hepple RT et al.
23 Caloric reduction improves skin disease: J Physiol Anthropol Appl Human Sci. 2003 Sep;22(5): 237-40. Nakamura H et al.; J Physiol Antropol Appl Human Sci. 2000 Sep;19(5): 225-8. Kouda K et al.
24 Caloric reduction into obese pregnant women has no negative effects for the fetus: J Nutr. 1984 Dec;114(12): 2247-55. Reynolds LK et al.
24 Calorie reduction programs maintain reproductive hormones and menstrual cycles 
Exp Gerontol. 2003 Jan-Feb;38(1-2): 35-46. Mattison JA et al.
24 In healthy, lean females, inappropriate calorie reduction reduces T3 levels: J Clin Endocrinol Metab. 2006 Aug;91(8): 3232-5. Fontana L et al.
24-25 HGH increases during fasting: Growth Horm IGF Res. 2002 Aug;12(4): 198-207. Norrelund H et al.
25 Dieting increases HGH levels in obese girls: J Clin Endocrinol Metab. 2002 Apr;87(4): 1885-93. Kasa-Vubu JZ et al.
25 Age-related Melatonin decline arrested by 30% calorie reduction: J Clin Endocrinol Metab. 2001 Jul;86(7): 3292-5. Roth GS et al. ; Exp Gerontol. 2003 Jan-Feb;38(1-2): 35-46. Mattison JA et al.
25 Long-term calorie reduction slows age-associated DHEA reductions: J Clin Endocrinol Metab. 2001 Jul;86(7): 3292-5. Roth GS. et al.
25 Calorie reduction increases adiponectin while decreasing fat:Obes Surg. 2006 Nov;16(11): 1425-32. Kotidis EV et al.
26 Caloric reduction mitigates kidney lesions: Gerontology. 2005 Mar-Apr;51(2): 83-93. Loupal G et al.
26 Calorie reduction decreases liver faty size 40%: Obes Surg. 2006 Jun;16(6): 697-701. Lewis MC et al.
26 Calorie reduction improves retina health: Bio Chem Biophys Res Commun. 2003 Sep 19;309(2): 457-63. Li D et al.
26 Calorie reduction slows cataracts development: Exp Eye Res. 2004 Jan;78(1): 151-8. Wang K et al.
26 Calorie reduction delays onset of glaucoma: J Glaucoma. 1997 Feb;6(1): 18-22. Li Y et al.
26 30-year studies on non-human primates indicate universal affect across species with calorie reduction: Microsc Res Tech. 2002 Nov 15;59(4): 335-8. Lane MA et al
26 Reducing calories every other day offers benefits: Med Hypotheses. 2006;67(2): 209-11. Johnson JB et al.
33 Ghrelin causes you to feel hungry and increase overall food intake: Diabetes. 2006 Nov;55(11): 3038-46. Chelikani PK et al.
33 Ghrelin moves food out of stomach quickly: J Clin Endocrinol Metab. 2006 Sep;91(9): 3296-302. Levin F et al.
33 Eating protein suppresses ghrelin: J Clin Endocrinol Metab. 2006 Aug;91(8): 2913-9. Bowen J.
34 Protein increases GLP-1, decreasing appetite: J Clin Endocrinol Metab. 2006 Aug;91(8): 2913-9. Bowen J et al.
40 R-Lipoic Acid reduces body weight and improves insulin sensitivity: Hormones (Athens). 2006 Oct-Dec;5(4): 251-8. Kamenova P.
40 R-Lipoic Acid can be effective in controlling neurological damage: Invest Ophthalmol Vis Sci. 2006 Sep;47(9): 4077-82. Roberts R et al.; Diabetes Care. 2006 Nov;29(11): 2365-70. Ziegler D et al.
40 R-Lipoic Acid can decrease glycation: Pharmazie. 2005 Oct;60(10): 772-5. Thirunavukkarasu V et al.
40 Chromium is efficient in treating insulin resistance: Diabetes Care. 2006 Dec;29(12): 2764-5. Martin J et al.; Folia Med. (Plovdiv). 2005;47(3-4): 59-62. Vladeva SV et al.; Mutat Res. 2006 Nov 7;610(1-2): 93-100. Pattar GR et al.
40 Cinnamon extract has anti-diabetic potency and improves insulin sensitivity: Eur J Clin Invest. 2006 May;36(5): 340-4. Mang B et al.; Phytomedicine. 2007 Jan;14(1): 15-22. Subash Babu P et al.
40 Vanadium may improve diabetic condition: Arch Biochem Biophys. 2005 Aug 15;440(2): 158-64. Mehdi MZ et al.; J Vet Sci. 2006 Dec;7(4): 391-5. Kim JM et al.; Clin Calcium. 2005 Jan;15(1): 49-57. Sakurai H.

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